FORMULATION AND CHARACTERIZATION OF PRAVASTATIN SODIUM SOLID DISPERSION FOR SOLUBILITY ENHANCEMENT

Solid dispersion is a most simple and efficient technique for increasing the aqueous solubility of a drug. PEG 8000, PVP K 30 and SLS solid dispersion were used to prepare at weight ratios of 1:1, 1:2, 1:4 and 1:8, using three different preparation methods, physical trituration, kneading and solvent evaporation values of First order was maximum i.e. 0.917 hence indicating drug release from formulations was found to follow first order kinetics. The present investigations showed that solubility of Pravastatin sodium was markedly increased by its solid dispersion using PVP K30 as carrier. The formulation SDF8 containing (1:8) shows highest dissolution rate. Hence the solid dispersion a way is useful technique in providing fastest onset of action of Pravastatin sodium as well as enhanced dissolution rate.