FORMULATION AND EVALUATION OF PRONIOSOMAL GEL OF OLMESARTAN

Proniosomes are dry free flowing formulations of surfactant- coated carrier, which on rehydration by agitation in hot water, produces a multi-lamellar niosomal suspension suitable for administration. Since, these proniosomal are available in dry form of powders, they have benefit in transportation, distribution, processing, packaging, and storage. It can provide optimal flexibility, metered unit dosing in capsule and stability. This versatile drug delivery system has the potential to be used as the carriers for many of the active pharmaceutical components. Proniosomes are microscopic lamellar vesicles, combine with nonionic surfactants (Span, Tween etc) and cholesterol followed by the addition of an aqueous media. The arrangement of the nonionic surfactants are in such a way that the hydrophilic portion phase outward and the hydrophobic ends are in opposite direction to form a bilayer