FORMULATION OF BILAYERED TABLET OF LOSARTAN POTASSIUM AND AMLODIPINE

V.P.Pandey
Department of Pharmacy, Annamalai University, Annamalainagar – 608002, Tamilnadu, India
R.Sathish Kumar
Department of Pharmacy, Annamalai University, Annamalainagar – 608002, Tamilnadu, India
A.Sathish Babu
The Madras Pharmaceuticals, Karapakkam. Chennai – 600096, Tamilnadu, India

Losartan potassium ,Amlodipine ,Bilayered tablet ,Antihypertensive. ,

In the combined formulation of amlodipine and losartan, amlodipine may be locked in inside of the formulation due to gelation of losartan and formulation with simple mixing of two have very poor storage stability. To avoid such problem, bilayer tablet of losartan and amlodipine is tried in present study. Five formulati ons (F1, F2, F3, F4 and F5) of bilayer tablet were prepared and evaluated for physical parameters and in vitro study. One bilayer tablet formulation (F5) was found suitable in evaluation. It was subject to stability study for 45 days at 25 o C/ 60 % RH as per ICH guidelines and found stable.

4 , 3 , 2014